ADEBAR Project

co-funded by 

Internal Security Fond of
the European Union

Journal Article

Pulver B, Fischmann S, Gallegos A, Christie R. EMCDDA framework and practical guidance for naming cathinones. Drug Testing and Analysis. Published online February 22, 2024;1-27.  doi:10.1002/dta.3662

Brandt SD, Kavanagh PV, Westphal F, Pulver B, Schwelm HM, Stratford A, Auwärter V, Halberstadt AL. Analytical and behavioral characterization of N-ethyl-N-isopropyllysergamide (EIPLA), an isomer of N6–ethylnorlysergic acid N,N-diethylamide (ETH-LAD). Drug Testing and Analysis. 2024;16(2):187-198.  doi:10.1002/dta.3530

Pulver B, Riedel J, Schönberger T, Halter S, Lucas T, Opatz T, Grafinger KE, Scheu M, Zschiesche A, Pütz M, Pützer K, Westphal F, Auwärter V. Pharmacology, prevalence in Germany, and analytical data of cyclobutylmethyl‐ and norbornylmethyl‐type synthetic cannabinoid receptor agonists. Drug Testing and Analysis. Published online January 9, 2023:dta.3427. doi:10.1002/dta.3427

Hemmer S, Wagmann L, Pulver B, Westphal F, Meyer MR. In Vitro and In Vivo Toxicometabolomics of the Synthetic Cathinone PCYP Studied by Means of LC-HRMS/MS. Metabolites. 2022;12(12):1209. doi:10.3390/metabo12121209

Pulver B, Riedel J, Schönberger T, Halter S, Lucas T, Opatz T, Grafinger KE, Scheu M, Zschiesche A, Pütz M, Pützer K, Westphal F, Auwärter V. Pharmacology, prevalence in Germany, and analytical data of cyclobutylmethyl‐ and norbornylmethyl‐type synthetic cannabinoid receptor agonists. Drug Testing and Analysis. Published online January 9, 2023:dta.3427. doi:10.1002/dta.3427

Kavanagh PV, Westphal F, Pulver B, Schwelm HM, Stratford A, Auwärter V, Chapman SJ, Halberstadt AL, Brandt SD. Analytical profile of the lysergamide 1cP-AL-LAD and detection of impurities. Drug Testing and Analysis. (Published online) doi:10.1002/dta.3397 

Pulver B, Fischmann S, Gallegos A, Christie R. EMCDDA framework and practical guidance for naming synthetic cannabinoids. Drug Testing and Analysis. Published online November 28, 2022:dta.3403. doi:10.1002/dta.3403​​​​​​​

Pulver B, Riedel J, Westphal F, Luhn S, Schönberger T, Schäper J, Auwärter V, Luf A, Pütz M. A new synthetic cathinone: 3,4-EtPV or 3,4-Pr-PipVP? An unsuccessful attempt to circumvent the German legislation on new psychoactive substances. Drug Testing and Analysis. Published online September 22, 2022. doi:10.1002/dta.3371

Wagmann L, Stiller RG, Fischmann S, Westphal F, Meyer MR. Going deeper into the toxicokinetics of synthetic cannabinoids: in vitro contribution of human carboxylesterases. Arch Toxicol. 2022;96(10):2755-2766. doi:10.1007/s00204-022-03332-z

Brandt SD, Kavanagh PV, Westphal F, Pulver B, Schwelm HM, Whitelock K, Stratford A, Auwärter V, Halberstadt AL. Analytical profile, in vitro metabolism and behavioral properties of the lysergamide 1P-AL-LAD. Drug Testing and Analysis. 2022;14(8):1503-1518. doi:10.1002/dta.3281

Pulver B, Fischmann S, Westphal F, Schönberger T, Schäper J, Budach D, Jacobsen-Bauer A, Dreiseitel W, Zagermann J, Damm A, Knecht S, Opatz T, Auwärter V, Pütz M. The ADEBAR project: European and international provision of analytical data from structure elucidation and analytical characterization of NPS. Drug Testing and Analysis. 2022;14(8):1491-1502. doi:10.1002/dta.3280, open access

Pulver B, Schönberger T, Weigel D, Köck M, Eschenlohr Y, Lucas T, Podlesnik N, Opatz T, Dreiseitel W, Pütz M, Schäper J, Jacobsen-Bauer A, Auwärter V, Westphal F. Structure elucidation of the novel synthetic cannabinoid Cumyl-Tosyl-Indazole-3-Carboxamide (Cumyl-TsINACA) found in illicit products in Germany. Drug Testing and Analysis. 2022;14(8):1387-1406. doi:10.1002/dta.3261

Brandt SD, Kavanagh PV, Westphal F, Pulver B, Morton K, Stratford A, Dowling G, Halberstadt AL. Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1‐valeroyl‐ d ‐lysergic acid diethylamide (1V‐LSD). Drug Testing and Analysis. 2022;14(4):733-740. doi:10.1002/dta.3205

Pulver B, Riedel J, Schönberger T, Pütz M, Schäper J, Kunert N, Putzer K, Hermann G, Auwärter V, Westphal F. Dataset allowing for the identification of three new synthetic cannabimimetics featuring a norbornyl methyl side chain by spectrometric and spectroscopic techniques. Data Brief. 2021;39:107628. doi:10.1016/j.dib.2021.107628

Pulver B, Riedel J, Schönberger T, Pütz M, Schäper J, Kunert N, Putzer K, Hermann G, Auwärter V, Westphal F. Comprehensive structural characterisation of the newly emerged synthetic cannabimimetics Cumyl-BC[2.2.1]HpMeGaClone, Cumyl-BC[2.2.1]HpMINACA, and Cumyl-BC[2.2.1]HpMICA featuring a norbornyl methyl side chain. Forensic Chemistry. 2021;26:100371. doi:10.1016/j.forc.2021.100371

Grafinger KE, Vandeputte MM, Cannaert A, Ametovski A, Sparkes E, Cairns E, Juchli PO, Haschimi B, Pulver B, Banister SD, Stove CP, Auwärter V. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays. Drug Test Anal. 2021;13(7):1412-1429. doi:10.1002/dta.3054

Haschimi B, Grafinger KE, Pulver B, Psychou E, Halter S, Huppertz LM, Westphal F, Pütz M, Auwärter V. New synthetic cannabinoids carrying a cyclobutyl methyl side chain: Human phase I metabolism and data on human cannabinoid receptor 1 binding and activation of Cumyl-CBMICA and Cumyl-CBMINACA. Drug Testing and Analysis. 2021;13(8):1499-1515. doi:10.1002/dta.3038

Halter S, Pulver B, Wilde M, Haschimi B, Westphal F, Riedel J, Pütz M, Schönberger T, Stoll S, Schäper J, Auwärter V. Cumyl‐CBMICA: A new synthetic cannabinoid receptor agonist containing a cyclobutyl methyl side chain. Drug Test Anal. 2021;13(1):208-216. doi:10.1002/dta.2942

Hemmer S, Manier SK, Fischmann S, Westphal F, Wagmann L, Meyer MR. Comparison of Three Untargeted Data Processing Workflows for Evaluating LC-HRMS Metabolomics Data. Metabolites. 2020;10(9):378. doi:10.3390/metabo10090378

Wagmann L, Frankenfeld F, Park YM, Herrmann J, Fischmann S, Westphal F, Müller R, Flockerzi V, Meyer MR. How to Study the Metabolism of New Psychoactive Substances for the Purpose of Toxicological Screenings-A Follow-Up Study Comparing Pooled Human Liver S9, HepaRG Cells, and Zebrafish Larvae. Front Chem. 2020;8:539. doi:10.3389/fchem.2020.00539

Gampfer TM, Wagmann L, Park YM, Cannaert A, Herrmann J, Fischmann S, Westphal F, Müller R, Stove CP, Meyer MR. Toxicokinetics and toxicodynamics of the fentanyl homologs cyclopropanoyl-1-benzyl-4´-fluoro-4-anilinopiperidine and furanoyl-1-benzyl-4-anilinopiperidine. Arch Toxicol. 2020;94(6):2009-2025. doi:10.1007/s00204-020-02726-1

Gampfer TM, Wagmann L, Richter MJ, Fischmann S, Westphal F, Meyer MR. Toxicokinetic Studies and Analytical Toxicology of the New Synthetic Opioids Cyclopentanoyl-Fentanyl and Tetrahydrofuranoyl-Fentanyl. J Anal Toxicol. 2020;44(5):449-460. doi:10.1093/jat/bkaa010

Metternich S, Fischmann S, Münster-Müller S, Pütz M, Westphal F, Schönberger T, Lyczkowski M, Zörntlein S, Huhn C. Discrimination of synthetic cannabinoids in herbal matrices and of cathinone derivatives by portable and laboratory-based Raman spectroscopy. Forensic Chemistry. 2020;19:100241. doi:10.1016/j.forc.2020.100241

Giorgetti A, Mogler L, Haschimi B, Halter S, Franz F, Westphal F, Fischmann S, Riedel J, Pütz M, Auwärter V. Detection and phase I metabolism of the 7-azaindole-derived synthetic cannabinoid 5F-AB-P7AICA including a preliminary pharmacokinetic evaluation. Drug Test Anal. 2020;12(1):78-91. doi:10.1002/dta.2692

Metternich S, Zörntlein S, Schönberger T, Huhn C. Ion mobility spectrometry as a fast screening tool for synthetic cannabinoids to uncover drug trafficking in jail via herbal mixtures, paper, food, and cosmetics. Drug Test Anal. 2019;11(6):833-846. doi:10.1002/dta.2565

Haschimi B, Mogler L, Halter S, Giorgetti A, Schwarze B, Westphal F, Fischmann S, Auwärter V. Detection of the recently emerged synthetic cannabinoid 4F-MDMB-BINACA in “legal high” products and human urine specimens. Drug Test Anal. 2019;11(9):1377-1386. doi:10.1002/dta.2666

Bachelor theses 

Bachelor thesis of Nika Podlesnik: “Synthesis Of Potential Cannabimimetics With Space-Filling Substituents On The Indole Nitrogen”, IMC Fachhochschule Krems 2022

Bachelor thesis of Grete Gollong: „Synthesis of potential cumyl-CBMICA-type cannabimimetics.“[German] Hochschule Fresenius Idstein, 2020

Bachelor thesis of Jan Riedel: „Verification of the distinguishability of structurally similar new psychoactive substances using nuclear magnetic resonance spectroscopy and mass spectrometry.” [German], Hochschule Fresenius in cooperation of the BKA, June 2019

Master theses

Master thesis of Marlene Rechberger: “Cross Calibration for quantitative determination of Cathinone derivatives via UHPLC-UV/Vis”, Ludwig-Maximilians-Universität München, 2021

Master thesis of Sarah Resch: „Quantification of synthetic cannabinoids via cross calibration using HPLC-UV detection.“ [German], Technische Universität Darmstadt, 2021

Master thesis of Patrick Enders: „Synthesis of azaindole-derived cannabimimetics“[German] Johannes-Gutenberg-Universität Mainz, 2019

Master thesis of Constance Braouet: „Investigation on the Application of Low-Field Nuclear Magnetic Resonance Spectroscopy in Forensic Analyses”, Hochschule Fresenius in cooperation with the BKA, June 2019

Master thesis of Johann-Arthur Schaser: „LC-ESI- and ambient MS studies on the fragmentation behavior of positional isomers of new psychoactive substances and inter-instrument transferability of MS/MS spectra”, Hochschule Fresenius in Kooperation mit dem Hessischen Landeskriminalamt, June 2018

Doctoral theses

Doctoral thesis Benedikt Pulver, Pharmacological Assessment of Synthetic Cannabinoid Receptor Agonists, their Semi-Systematic Naming and Analytical Characterization of Novel Psychoactive Substances, Universität Freiburg, 2023

Doctoral thesis Sonja Metternich, Advantages and limitations of spectroscopic, chromatographic and electrophoretic methods for the characterisation of synthetic cannabinoids and synthetic cathinone derivatives, Universität Tübingen, 2020

Other scientific theses

Final report to the subproject „Development of quantitative analytical methods for substances newly appearing on the drug market (benzodiazepines) by means of cross-calibration with high-pressure liquid chromatography“[German], Mario Preuß, LKA Berlin KTI 41, 2021

Final report to the subproject „Cross-calibration of doping agents using HPLC-UV of the EU project ADEBAR plus“ [German], F. Ritterbusch/S. Knecht, Generalzolldirektion, Bildungs- und Wissenschaftszentrum, Wissenschaftliches Referat, Frankfurt, 2021